Raziskave mikro RNA pri govedu, prašičih, ovcah in kokoših

Neža POGOREVC, Minja ZORC, Tanja KUNEJ

Povzetek


Mikro RNA (miRNA) so kratke nekodirajoče RNA, ki imajo pomembno funkcijo pri uravnavanju izražanja genov. Polimorfizmi v prekurzorjih miRNA, v tarčnih genih ali znotraj komponent, ki sodelujejo pri mehanizmu utišanja genov, pomembno prispevajo k fenotipski raznovrstnosti pri živalih. Zaradi te vloge so miRNA postale predmet naraščajočega zanimanja za raziskave v povezavi s proizvodnimi lastnostmi v živinoreji. V članku smo predstavili primere povezav med miRNA in fenotipom pri štirih vrstah rejnih živali: govedu, prašičih, ovcah in kokoših. Večina raziskav o delovanju miRNA je usmerjenih predvsem v mišično in maščobno tkivo, spolne žleze, razvoj zarodka in imunski odziv organizma. Delovanje miRNA vpliva tudi na produktivnost živali in posledično na ekonomsko uspešnost prireje. S tem, ko razumemo delovanje miRNA v različnih bioloških procesih, jih lahko uporabljamo za razvijanje novih strategij za izboljšanje produktivnosti rejnih živali.

Ključne besede


živinoreja; genetika; mikro RNA

Celotno besedilo:

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Literatura


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DOI: http://dx.doi.org/10.14720/aas.2015.106.1.2

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